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. 2016 Mar 8;11(4):2792–2800. doi: 10.3892/ol.2016.4315

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Copyright: © Yu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — TMZ plus MET significantly induced apoptosis in GSCs. (A) U87-GSCs and (B) C6-GSCs (2×10⁵ cells) were cultured in the presence of 0.4 mmol TMZ, 20 mmol MET or TMZ plus MET. The cells were harvested after 48 h and stained with Annexin V-FITC, propidium iodide, and analyzed by flow cytometry. (C) Quantitative analysis of the early and late apoptosis rate. Results are representative of three independent experiments (*P<0.05, compared with single agents). GSCs, glioma stem cells; TMZ, temozolomid; MET, metformin.