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. 2016 Mar 30;6:23661. doi: 10.1038/srep23661

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Copyright © 2016, Macmillan Publishers Limited

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(A) Immunofluorescence of MERRF hiPSC-CMs stained with cardiomyocyte markers, including cTNT, α-actinin, MYL7 and MYL2. Nuclei were counterstained with Hoechst 33342 (blue). Scale bar, 10 μm. (B) mtDNA A8344G mutation rate quantified by pyrosequencing of MERRF hiPSCs and MERRF hiPSC-derived cardiomyocytes. M1-CM and M2-CM, MERRF hiPSC-derived cardiomyocytes carried mtDNA A8344G mutation. M1^ctrl-CM, hiPSC-derived cardiomyocyte carried normal mtDNA.