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. 2016 Mar 30;6:23661. doi: 10.1038/srep23661

Figure 6. Fragmented mitochondrial morphology in MERRF-hiPSC-derived cardiomyocytes.

Figure 6

(A) Mitochondria were stained with MitoTracker Red, and immunofluorescence analysis indicated the cardiomyocyte marker α-actinin in MERRF hiPSC-derived cardiomyocytes. (B) Quantitative data showing mitochondrial subtypes based on a microP analysis. (C) Ultra-structure of M1-CM, M2-CM and M1Ctrl–CM. (D) Western blot revealing the expression of the mitochondrial fission proteins. (E) Quantitative result of mitochondrial fission proteins, the data represented mean ± SEM, n = 3. M1-CM and M2-CM, MERRF hiPSC-derived cardiomyocytes carried mtDNA A8344G mutation. M1ctrl-CM, hiPSC-derived cardiomyocyte carried normal mtDNA.