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. 2016 Mar 30;6:23474. doi: 10.1038/srep23474

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Copyright © 2016, Macmillan Publishers Limited

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Open (ATP-bound) (PDB id: 4B9Q) and Closed (ADP-bound) (PDB id: 2KHO) end-points X-ray structure are displayed. NBD lobe I is green, lobe II is blue, linker is violet, βSBD is represented in yellow, and αSBD helices in red. Peptide-substrate bound to the SBD binding cavity of the open conformation induces the ATP hydrolysis and a large structural rearrangement to the closed conformation. This, after nucleotide exchange mediated by Nucleotide Exchange Factors (NEF), undergoes to another conformational transition, with βSBD docked to the NBD and a reduced the affinity for the peptide-substrate.