Table 1.
Day 4 | Day 7 | Day 10 | Day 14 | |||||
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Case | Control | Case | Control | Case | Control | Case | Control | |
Inflammatory cell density (cell/HPF) | 145 ± 56 Cell/HPF (++++) |
98 ± 35 Cell/HPF (++++/+++) |
91 ± 33 Cell/HPF (+++/+++) |
72 ± 31 Cell/HPF (+++/++) |
67 ± 28 Cell/HPF (+++/++) |
29 ± 15 Cell/HPF (++/+) |
21 ± 14 Cell/HPF (+) |
12 ± 9 Cell/HPF (+/−) |
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Inflammatory cell type | 100% PMN, no MN | 98% PMN, 2% MN | 93% PMN, 7% MN | 70% PMN, 30% MN | 80% PMN, 20% MN | 5% PMN, 95% MN | 30% PMN, 70% MN | No PMN, 100% MN |
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Granulation tissue formation | — | −/+ | + | ++ | ++ | +/− | +/− | — |
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Edema | ++ | ++ | ++/+ | + | + | +/− | +/− | — |
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Fibroblast density | 3 ± 2/HPF | 5 ± 2/HPF | 9 ± 4/HPF | 13 ± 7/HPF | 23 ± 12/HPF | 18 ± 8/HPF | 22 ± 10/HPF | 20 ± 11/HPF |
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Fibroblast activity | — | — | −/+ | + | ++ | +/++ | ++ | ++ |
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Basal layer | Damaged | Damaged | Marked in margins | Marked in margins | Join completed | Join completed | Completed | Completed |
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Increased thickness of epidermis in the edge of wound | No epidermis in the edge | No epidermis in the edge | 4 ± 1 layers' epidermis | 4 ± 1 layers' epidermis | 2 ± 1 layers' epidermis | 2 ± 1 layers' epidermis | 1 ± 1 layers' epidermis | No epidermis in the edge |
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Keratosis in the edge of wound | 2 ± 1 layers | 2 ± 1.5 layers | 3 ± 1.5 layers | 2 ± 1 layers | 6 ± 2 layers | 2 ± 1 layers | 3 ± 1 layers | 2 ± 1 layers |
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Number of hair follicles in the scar | 12 ± 5 necrotic follicles/LPF | 15 ± 6 necrotic follicles/LPF | 0 | 0 | 0 | 0 | 0 | 0 |
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Number of hair follicles in the margins | 20 ± 2 | 20 ± 2.5 | 22 ± 3 | 18 ± 2.6 | 25 ± 3.4 | 15 ± 1.4 | 28 ± 2.6 | 12 ± 1.4 |
Microscope: Olympus SZX research microscope. LPF (Low Power Field) is 100x and HPF (High Power Field) is 400x. Diameter of objective lens of LPF is 1.02 mm and HPF is 0.51 mm.