Figure 2. NECA increased low molecular weight (LMW) dextran extravasation and concentration in blood.

Mice received LMW dextran (i.v. via tail vein) at 3 h after NECA injection (n = 10 per group), and LMW dextran concentrations in forebrain (A₁), cerebellum (B₁), liver (C), and blood (D) were quantified 90 min later. BBB permeability was normalized to LMW dextran concentration in blood for LMW dextran concentrations in forebrain (A₂) and cerebellum (B₂). The bars represent means ± SEM. Significant differences were determined by the unpaired t test. ***p < 0.001; n.s. indicates no significant difference.