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. 2016 Mar 30;6:23817. doi: 10.1038/srep23817

Figure 7. Schematic diagram of the pramipexole-induced hypothermia-mediated neuroprotective mechanisms in SAH rats.

Figure 7

Blue colored letters and arrows indicate the pramipexole-induced hypothermia-mediated anti-apoptotic effect, and black colored letters and arrows indicate the SAH-induced pro-apoptotic pathway. To some extent, PI3K was activated under SAH conditions, but PI3K/AKT/GSK3β pathway is incomplete, and pramipexole-induced hypothermia promotes PI3K/AKT/GSK3β pathway activation in SAH. Red colored letters and arrows indicate the effects of PI3K inhibitor LY294002, AKT inhibitor MK-2206, and GSK3β inhibitor CHIR99021. PPX: pramipexole.