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. 2016 Mar 30;6:23817. doi: 10.1038/srep23817

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Copyright © 2016, Macmillan Publishers Limited

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(A,B) Schematic representation of the areas taken for assay. (A) Sham group. (B) Subarachnoid hemorrhage (SAH) group. (C) Design of dose-response experiment. (D) Experimental design for studying the effects of pramipexole-induced hypothermia and the possible mechanisms. Briefly, sixty-six rats (84 rats were used, 66 rats were survived) were randomly divided into 4 groups: normal group (n = 6), sham group (n = 12), SAH group (n = 12), and SAH + pramipexole group (n = 36). Among the 36 rats in SAH + pramipexole group, 24 rats were randomly subdivided into 4 groups: SAH + pramipexole + rewarming group (n = 6), SAH + pramipexole + LY294002 group (n = 6), SAH + pramipexole + MK-2206 group (n = 6), and SAH + pramipexole + CHIR99021 group (n = 6). PPX: pramipexole.