Table I.

Immunostaining results for E-cadherin, vimentin, β-catenin, MMP-14 and c-kit expression in HNSCC22B cells.

	Lapatinib
Immunostaining	5 h	24 h	96 h
Control group
E-cadherin	++	++	+
Vimentin	0	0	0
β-catenin	+	+/++	+
MMP-14	0	0/+	0/+
c-kit	0	0	0
Lapatinib 0.5 µg
E-cadherin	++	++	+/++
Vimentin	0	0	0
β-catenin	++	++	++
MMP-14	0	0/+	0
c-kit	0	0	0
Lapatinib 2 µg
E-cadherin	++	++	++
Vimentin	0	0	0
β-catenin	++	+	++
MMP-14	0	0	0
c-kit	0	0	0

0, negative immunostaining; +, weak immunostaining; ++, moderate immunostaining; +++, strong immunostaining; MMP, matrix metalloproteinase; HNSCC, head and neck squamous cell carcinoma.