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(a)
| Antigen | aa | Candidate peptides that stimulate | Candidate peptides that stimulate | ||||
|---|---|---|---|---|---|---|---|
| pancreatic LN cell proliferationa | pancreatic LN cell secretion of IFNγ b | ||||||
| 3 weeks | 13 weeks | Diabetic | 3 weeks | 13 weeks | Diabetic | ||
| Control | 147–155 | − | − | − | − | − | − |
| Insulin | 39–47 | − | + | + | + | + | + |
| Gad65 | 178–186 | − | + | − | − | − | − |
| Gad65 | 546–554 | − | + | + | − | + | + |
| IGRP | 206–214 | − | + | + | − | + | + |
| ICAp69 | 78–86 | − | − | + | − | − | − |
| ZnT8 | 158–166 | − | + | + | − | − | − |
| ZnT8 | 282–290 | − | + | + | − | + | + |
| DβH | 233–241 | − | + | + | − | + | + |
