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. 2016 Mar 16;2016:3191638. doi: 10.1155/2016/3191638

Figure 2.

Figure 2

Antinociceptive effects of acute treatment with RSV + RO or PGB on latency time (s) in response to thermal stimulation in the fibromyalgia model. PGB was used as a positive control drug. Thermal hyperalgesia was assessed in the hot plate test, on the 4th day after onset of reserpine administration (0.25 mg/kg, s.c., once a day for three days), 30 min after treatment administration. Data are presented as mean ± SEM. ∗∗ p < 0.001 compared to control (SAL-SAL), ## p < 0.01 compared do RES-SAL group, § p < 0.05 compared to RES-RSV-RO, and §§ p < 0.01 compared to RES-RSV-RO. Statistical analysis was performed by one-way ANOVA followed by Bonferroni's post hoc test. n = 7 to 11 mice/group.