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. 2016 Mar 16;2016:3191638. doi: 10.1155/2016/3191638

Figure 4.

Figure 4

Effects of chronic treatment with RSV, RSV + RO, or PGB on reserpine-induced nociception in the fibromyalgia model in mice. On the 4th day, mice receiving reserpine (0.25 mg/kg, s.c., once a day for 3 days) and treated orally with RSV (100 mg/kg once a day for 4 days), RSV + RO (10 mg/kg once a day for 4 days), RO (10 mL/kg once a day for 4 days), or PGB (30 mg/kg once a day for 4 days) were tested through Von Frey stimulation for mechanical allodynia (a) and in the open field test for thermal hyperalgesia (b). Data are presented as mean ± SEM. ∗∗∗ p < 0.001 compared to control (SAL-SAL), # p < 0.05, ## p < 0.01, and ### p < 0.001 compared to RES-SAL group, and §§ p < 0.01 compared to RES-RSV-RO. Statistical analysis was performed by one-way ANOVA followed by Bonferroni's post hoc test. (a) n = 9 to 13 mice/group; (b) n = 7 to 8 mice/group. ∗∗ p < 0.01 compared to control (SAL-SAL).