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. 2016 Mar 25;22:254–263.

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Copyright © 2016 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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NGF facilitates the proliferation of murine Müller cells via ERK1/2 and AKT signaling. Proliferation of Müller cells increased following nerve growth factor (NGF) treatment as analyzed with 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. In addition, the TrkA receptor, extracellular signal-regulated kinases 1/2 (ERK1/2), or phosphatidylinositol 3-kinase (PI3K)/AKT inhibitor abolished the promotion of proliferation by NGF at the 24 h (A), 48 h (B), and 72 h (C) time points. n=6, * p<0.05, ** p<0.01, *** p<0.001.