Figure EV2. FDR and number of DMRs at different methylation difference theresholds.

1. Median false discovery rate (FDR) estimated by permutation analysis at different cutoffs for mean methylation changes of DMRs (Δ_Methylation).
2. Number of DMRs after filtering called at different mean methylation changes. The 10% Δ_Methylation cutoff is marked and indicates a fair balance between sensitivity and specificity while offering acceptable FDRs (9.7% in children, 11.4% in mothers).