Table I.
ER/HER2 status | Doubling Time (h) | Average GI50 (nM) | Average TGI (nM) | Average LC50 (nM) | |
---|---|---|---|---|---|
MDA-MB-468 | −/− | 62.8 | 1.4 | 2.8 | 11 |
SK-BR-3 | −/+ | 44.6 | 1.8 | 3.5 | 62 |
Hs 578T | −/− | 43.7 | 2.5 | 4.9* | 18* |
MCF7 | +/− | 44.2 | 2.3 | 5.8 | 410*** |
T-47D | +/− | 47.4 | 5.8 | 92** | > 5,000 |
MDA-MB-231 | −/− | 31.1 | 4.9 | 132*** | > 5,000 |
HCC1937 | −/− | 49.9 | 6.5 | > 5,000 | > 5,000 |
BT-549 | −/− | 20.9 | 8.4 | > 5,000 | > 5,000 |
One of the drugs did not reach this criterion;
two of the drugs did not reach this criterion;
three of the drugs did not reach this criterion