Table 3.
Haplotype Analysis of miR-146aC > G, miR-149T > C, miR-196a2T > C, and miR-499A > G gene Variants Among Patients With RM and Controls.a
| Haplotypes | Patients, n = 400 (%) | Control, n = 600 (%) | OR | 95% CI | P Value |
|---|---|---|---|---|---|
| CTTAb | 90 (22.5%) | 213 (35.5%)c | 0.53 | 0.39-0.70 | .0001c |
| GTCAc | 61 (15.3%) | 85 (14.1%)c | 1.09 | 0.76-1.55 | .6484 |
| GTTAc | 70 (17.5%) | 86 (14.3%)c | 1.26 | 0.89-1.78 | .1829 |
| GTTG | 8 (2.0%) | 22 (3.6%) | 0.53 | 0.23-1.21 | .1843 |
| CCCAc | 35 (8.7%) | 56 (9.3%)c | 0.93 | 0.59-1.45 | .8227 |
| CTTG | 14 (3.5%) | 8 (1.3%) | 2.68 | 1.11-6.46 | .0274c |
| CTCAc | 26 (6.5%) | 55 (9.1%)c | 0.68 | 0.42-1.11 | .1555 |
| CTCGc | 38 (9.5%) | 11 (1.8%) | 5.62 | 2.83-11.13 | .0001c |
| CCTAc | 27 (6.7%) | 19 (3.1%) | 2.21 | 1.21-4.03 | .0128c |
| GCTA | 6 (1.5%) | 8 (1.3%) | 1.12 | 0.38-3.27 | 1.0000 |
| CCTG | 2 (0.5%) | 10 (1.6%) | 0.29 | 0.06-1.36 | .1384 |
| GTCG | 11 (2.7%) | 18 (3.0%) | 0.91 | 0.42-1.95 | .8505 |
| GCCA | 3 (0.75%) | 9 (1.5%) | 0.49 | 0.13-1.84 | .3806 |
| GCTG | 8 (2.0%) | – | |||
| CCCG | 1 (0.25%) | – |
Abbreviations: CI, confidence interval; NS, not significant; OR, odds ratio; RM, recurrent miscarriage.
aHaplotypes were generated from multilocus diploid data based on a Gibbs sampling strategy (Arlequin v3.5).
bStatistically significant protective haplotypes.
cThe difference in haplotype frequencies between the case and control groups for the prevalent haplotypes (prevalence more than 5% in either cases or controls) was analyzed for statistical significance using Fisher exact test with Bonferroni correction, and ORs are reported within the 95% confidence limits.
dStatistically significant RM predisposing haplotypes.