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. 2016 Mar 8;113(12):3323–3328. doi: 10.1073/pnas.1519608113

Fig. 3.

Fig. 3.

MOG AAbs mediate the disease-promoting effects of B cells. (A) Active EAE in C57BL/6J mice after i.v. injection of MOG mAAb or of an isotype control antibody (control Ab). (B) Active EAE in C57BL/6J mice after i.t. injection of human IgG containing MOG AAb or control human IgG. (C) Effects of i.t.-applied MOG mAAb in TMOG-GFP cell-induced transfer EAE of Lewis rats. Clinical scores are shown. Arrows, time of antibody injection. Data are presented as mean ± SEM. n = 4–16 pooled from two or three independent experiments.