Fig. 7.

Signaling role of interface 2 in the bacterial chemosensory array. Color schemes for the cartoons match those in Fig. 1. Interface 2 interactions (red circles) between CheA-P5 and CheW assemble receptor core complexes into networked receptor teams that behave as a multi-subunit allosteric enzyme in response to binding of attractant ligands. Kinase-ON complexes (Upper) may have more dynamic structures compared with kinase-OFF complexes (Lower, pale cartoons). Static complexes may disfavor interface 2 interactions, leading to slow disassembly of kinase-OFF teams. See the text for additional discussion.