Fig. 6.

Centromere clusters are often in the nuclear interior. (A) Box-and-whisker plots showing the distribution of radial positions of a centromere as a function of the number of other centromeres it is in contact with. The widths of the boxes are proportional to the square root of the sample size. Displayed here are plots for chromosomes 1 and 6 and centromeres from all chromosomes combined (see SI Appendix, Fig. S5A). (B) Schematic diagram of a centromere cluster, illustrating that centromeres in a central cluster are often shielded by their chromosome arms from approaching positions close to the NE.