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. Author manuscript; available in PMC: 2016 Aug 8.
Published in final edited form as: Nat Struct Mol Biol. 2016 Feb 8;23(3):217–224. doi: 10.1038/nsmb.3170

Figure 6. Pol2 footprint on the atomic model of CMG helicase.

Figure 6

(a) The two-domain architecture of Pol2, the catalytic subunit of the Pol ε complex. The N-terminal half contains the polymerase and exonuclease activities. The C-terminal half is homologous to a B-family polymerase but without enzymatic activity. The red vertical bars indicate the locations of the residues in Pol2 that crosslink to subunits of CMG16. (b) Surface-rendered front side and top views of the previously reported 3D density map of the CMG-Pol ε complex (EMDB 6465)16. (c) The top and bottom panels are corresponding front side and top views of the atomic model of CMG helicase. The helicase residues that cross-link to Pol2 are shown in blue spheres. The green oval represents the approximate Pol2 position on CMG as predicted from the crosslink footprint.