Table 1.

Summary of all published FXYD5 modifications and mutations.

Residues	Location	Modification	Function	Expression system	References
1–21	N-terminus	Signal peptide	Plasma membrane targeting	Xenopus oocytes	Lubarski et al., 2005
22–145	N-terminus	O-Glycosylation	Up-regulated in cancer?	PLC/PRF/5	Tsuiji et al., 2003
S163	C-terminus	Phosphorylation	Reduce association with Na+/K+-ATPase	MDCK	Miller and Davis, 2008b
C168, C170	C-terminus	Palmitoylation	Not tested	T-cells	Martin et al., 2012
179AYRVINMKES188	C-terminus	Splice variant	Not tested	Dendritic cells	Lubarski et al., 2007
A150, I160,L161	Transmembrane	Mutation to G,M,A	Reduce association with Na+/K+-ATPase	Xenopus oocytes, HEK293	Lubarski et al., 2007
R145	N-terminus, membrane interphase	Mutation to G	Increase association with Na+/K+-ATPase	HEK293	Lubarski et al., 2014