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. 2016 Mar 30;10:63. doi: 10.3389/fnbeh.2016.00063

Figure 2.

Figure 2

Activity of hM3Dq DREADD. Injection of a depolarizing current step (300 pA) evoked action potential firing in labeled mPFC neuron (n = 10; 6 mice: A). Application of CNO (5 mins) caused membrane depolarization and triggered action potential bursting (n = 19; 6 mice: B). (C) Quantification of the dose dependent increases in membrane depolarizations and firing rates (D). CNO induced depolarizations and firing bursts were abolished by L-NAME (500 μM; E). (F) Quantification of reduction in action potential frequency by L-NAME. Values represent means ± SEM. *p < 0.001 ANOVA followed by Tukey’s post hoc test.