Table 3.

Important metabolites defining the sub-group of nine SDB brains shown in Fig. 4. ^⁎Matches retention time of standard. ^⁎⁎Does not match the retention time of the standard therefore is an isomer of the named compound.

m/z	Rt min	Metabolite	P value	Ratio	VIP
P 227.114	10.3	⁎⁎Carnosine isomer	0.0020	8.34	1.70
N 145.014	6.3	⁎⁎Oxoglutarate isomer	0.0310	3.91	1.35
N 195.051	14.4	⁎Gluconic acid	< 0.001	3.30	2.32
N 159.103	4.9	Ethyl-hydroxyhexanoate	0.0020	2.95	1.35
N 181.072	14.3	⁎Sorbitol/mannitol/iditol/dulcitol	< 0.001	2.94	2.22
N 151.061	13.2	⁎Xylitol/ribitol/arabinotol	< 0.001	2.38	1.56
N 209.067	14.4	⁎Sedoheptulose	< 0.001	2.34	2.20
N 252.088	8.1	N-Acetylvanilalanine	< 0.001	2.06	2.15
N 121.051	12.1	⁎Erythritol/threitol	< 0.001	2.00	1.65
N 164.072	10.4	⁎Phenylalanine	< 0.001	1.88	1.80
N 178.072	12.9	⁎Glucosamine	0.0010	1.88	1.48
N 130.087	11.2	⁎Leucine	< 0.001	1.66	1.54
N 202.109	5.5	⁎⁎O-Acetylcarnitine isomer	< 0.001	1.60	2.13
P 116.072	12.9	⁎Valine	< 0.001	1.58	1.62
N 103.004	16.1	⁎Malonate	0.0010	1.56	1.68
P 161.107	10.4	Tryptamine	0.0010	1.55	1.39
P 169.097	11.3	⁎Pyridoxamine	0.0010	1.53	1.34
N 114.056	13.2	⁎Proline	0.002	1.52	1.99
N 180.067	13.4	⁎Tyrosine	0.001	1.44	1.97
P 230.151	24.2	Gamma-Aminobutyryl-lysine	0.0280	1.42	1.62
N 220.083	12.3	⁎N-Acetyl-D-glucosamine	< 0.001	1.40	1.99
P 104.071	15.9	⁎4-Aminobutanoate	< 0.001	0.78	1.40
P 284.099	13.0	⁎Guanosine	< 0.001	0.58	1.63
N 273.039	15.7	1-Deoxy-D-altro-heptulose 7-phosphate	0.0020	0.49	1.47
N 171.007	15.4	⁎Glycerol 3-phosphate	0.0040	0.38	1.88
N 231.099	16.8	N2-Succinyl-L-ornithine	0.0110	0.36	2.07
P 248.024	10.8	Norepinephrine sulfate	< 0.001	0.32	1.48
P 305.098	17.2	⁎N-Acetyl-aspartyl-glutamate	0.0030	0.27	2.52
P 277.031	12.6	⁎⁎Phospho-gluconate isomer	0.0030	0.06	1.92