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. 2016 Feb 26;17(3):288. doi: 10.3390/ijms17030288

Figure 3.

Figure 3

Simple schematic representation of Gliotic scar mediated Rho-kinase (ROCK, blue circle) activation in neurons. Inhibitory molecules released by the glial scar include CSPGs, Nogo (Nogo66 and Amino Nogo), OMgP, RGM, Ephrin and semaphorins. Activation of receptors present on axon membranes (red shapes) signal change in Rho-ROCK activity within neurons resulting in growth cone collapse, neurite retraction and apoptosis. Black arrows reference signaling events from the glial scar that activate receptors on neurons that trigger internal signaling events (Grey arrows) that activate ROCK.