Table 2.

Important findings for extracellular vesicles in the context of NAFLD.

Key Study Findings		Disease Model	Vesicle Source	Methods	Citation
Rodent	NAFLD-inducing diet increases circulating EV abundance	HFD CDD	plasma	FC	[74,75,76]
	Circulating EV abundance correlates with NAFLD progression	CDD	plasma	FC	[75,76]
	NAFLD-inducing diet increases circulating liver-derived EVs	HFD CDD	plasma serum	RT-qPCR	[75,76,77]
	NAFLD-inducing diet changes circulating EV contents	CDD	plasma	LCMS WB	[75,76]
	NAFLD-inducing diet changes circulating EV interactions with cells	HFD	plasma	FC	[79]
Human	Circulating EV abundance correlates with NAFLD progression	NASH	plasma	FC	[72]
	Circulating EV contents can distinguish NAFLD from other liver diseases	NASH	plasma serum	FC microarray	[72,82]

Abbreviations: CDD = choline deficient diet, EV = extracellular vesicle, FC = flow cytometry, HFD = high-fat diet, LCMS = liquid chromatography with mass spectrometry, NAFLD = non-alcoholic fatty liver disease, NASH = non-alcoholic steatohepatitis, RT-qPCR = real-time quantitative polymerase chain reaction, WB = western blot.