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. 2016 Mar 15;129(6):1179–1189. doi: 10.1242/jcs.175307

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© 2016. Published by The Company of Biologists Ltd

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Fig. 4. — Microtubule and actin disruption completely disperses apical MyoVbT, but partly disperses apical ATP7B. (A) In cells not treated with nocadazole and/or cytocalasin D (−Noco/−CD) ATP7B (green) and MyoVbT (red) colocalize near the bile canaliculus. (B) Disruption of microtubules with Nocodazole (+Noco) disperses MyoVbT to numerous peripheral vesicles. ATP7B is also dispersed into vesicles following Nocodazole treatment, and a Nocodazole-insensitive pool remains associated on the apical membrane. (C) Disruption of actin polymerization with cyotchalasin D (+CD) also disperses ATP7B and MyoVbT into a discreet vesicular pool. This pool of vesicles is associated with the cortical actin adjacent to the bile canaliculus. Asterisk indicates a bile canaliculus. Scale bars: 2 µM.