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The strategy for isolation of TEX from plasma of a patient with cancer. Initially, a one-step mini-SEC is used to isolate total plasma exosomes. Next, TEX are captured on mAb-coated magnetic beads. The mAb selected for immune capture of TEX is specific for a tumor-associated antigen (TAA) overexpressed on tumor cells. Captured TEX are eluted from beads using acidified buffer. Following capture and elution, TEX retain morphologic integrity and mediate biological functions [83].
