Table 4.
Tumor-associated miRNAs in EVs/exosomes isolated from human body fluidsa
| Cancer type | miRNAs | Reference |
|---|---|---|
| OvCA | miR-21, miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-205, miR-2014 | 100, 107 |
| CerCA | miR-21, miR-146a | 117 |
| CRC | Let-7a, miR-1224, miR-150, miR-1246, miR-21, miR-23a miR-223 | 114 |
| GBM | miR-21, miR-320, miR-574-3p | 166, 167 |
| NSCLC | miR-151a, miR-30a-3p, miR-154-3p, miR-100, miR-629, miR-2006-5p | 107, 108, 168 |
| PROCA | miR-107, miR-1306, miR-141, miR-181a-2, and 8 others | 129, 169, 170 |
| RCC (stem cells) | miR-200c, miR-92, miR-141, miR-196, miR-29a, miR-29c, miR-650, miR-151 | 129 |
| HCC | miR-584, miR-517c, miR-378, and 8 others | 171 |
| AMLb | Let-7a, miR-9, miR-99b, miR-150, miR-155, miR-191, miR-223 | 172 |
a
EVs/exosomes were isolated from patients’ body fluids by various methods, and exosomes were not discriminated from EVs. The table presents a selected list of data to illustrate the diversity of miRNA contents in vesicles isolated from human body fluids.
b
miRNAs detected in supernatants of an AML cell line Molm-14.
Abbreviations: OVCA, ovarian carcinoma; CerCA, cervical carcinoma; GBM, glioblastoma; NSCLC, non-small cell lung cancer; PROCA, prostate carcinoma; RCC, renal cell carcinoma; AML, acute myeloid leukemia.