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. 2016 Mar 1;143(5):841–850. doi: 10.1242/dev.129320

Fig. 6.

Fig. 6.

Inhibition of Notch leads to increased histone acetylation at the Atoh1 promoter in supporting cells. (A) Inhibition of HDAC activity by trichostatin A (TSA) for 6 h induces Atoh1 expression in FACS-purified supporting cells (p27/GFP+). Values are mean±s.e.m.; n=3. (B) Inhibition of HAT activity by curcumin (Balasubramanyam et al., 2004) for 24 h blocks DAPT-induced Atoh1 activation in FACS-purified supporting cells (Lfng/GFP+). n=3. (C) Inhibition of Notch signaling (DAPT for 24 h) increases H3K9ac, as analyzed by ChIP-qPCR at the Atoh1 promoter in FACS-purified supporting cells (p27/GFP+). Values are mean±s.e.m.; n=3. *P<0.05, **P<0.005. See also Fig. S6.