FIGURE 8.

Competitive inhibition by SCl-DDR of the interactions between collagen type III and recombinant DDR2-Fc. Collagen type I, SCl-DDR₄, or SCl-DDR₆ were incubated with DDR1-Fc (A) or DDR2-Fc (B) for 1 h at room temperature before addition to plate-immobilized collagen type III. Bound DDR-Fc was detected with anti-Fc antibodies and measured as absorbance at 450 nm. Color code is as follows: collagen type I (gray); SCl-DDR₄ (red); SCl-DDR₆ (green); SCl (blue). Dashed lines show data for the denatured samples.