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. 2016 Jan 6;291(9):4442–4452. doi: 10.1074/jbc.M115.671057

FIGURE 1.

FIGURE 1.

Ubp7 is linked to the DNA damage response. a, ERC values between the Ubp7 and DNA repair pathways show statistically significant correlations with HR and NER but not with base excision repair (BER), mismatch repair (MMR), nonhomologous end joining (NHEJ), or endocytosis (Endocyt). Violin plots show the distribution of ERC values between the UBP7 and DNA repair pathways. Curves show a smoothed representation of their density, whereas tick marks show the exact values. p values reflect the significance of elevation above the genome-wide distribution. b, 5-fold serial dilutions of wild-type, ubp7Δ, and rad51Δ (control) strains grown on YPD, YPD with 150 mm HU, YPD with 0.02% MMS, or YPD and irradiated with 100 Gy of γ radiation (IR). c, 5-fold serial dilutions of the same strains as in a grown on SC with 0.03% DMSO or the indicated cisplatin (in DMSO) concentrations. d, WT, ubp7Δ, and rad51Δ cells were measured for cell viability by plating on YPD medium containing the indicated doses of HU and compared with their corresponding untreated YPD control. e, wild-type, ubp7Δ, and rad51Δ cultures were grown in SC medium and plated on SC plates containing the indicated concentrations of HU. Plates were imaged 24 h after plating.