FIGURE 7.

Structure of Ro-435054 bound to α_IIbβ₃ headpiece. A, chemical structure of Ro-435054. B, overlay of α_IIbβ₃ complex crystal structures with Ro-435054 (green carbons) and γC dodecapeptide (gray carbons), after superimposition on main chain atoms of the βI domain. Only α_IIbβ₃ residues from the Ro-435054 complex are illustrated with carbons colored wheat (α_IIb) or cyan (β₃). The MIDAS Mg²⁺ is shown as a gray sphere, and water molecules are shown as small red spheres. Black dashed lines represent hydrogen bonds and metal coordinations of the Ro-435054 structure.