TABLE 1.
Animal characteristics of rats showing SHAM controls and ABHF
The following abbreviations are used: LV, left ventricle; BW, body weight; RV, right ventricle; IVSd, interventricular septum in diastole; PWd, posterior wall thickness in diastole; LVDd/s, left ventricular diameter in diastole or systole, respectively; FS, fractional shortening; LAD, left atrial diameter; HR, heart rate; CO, cardiac output; LVOT, left ventricular outlet tract.
| SHAM | ABHF | |
|---|---|---|
| Organ weights | ||
| Number (n) | 9 | 5 |
| BW (g) | 364 ± 6 | 353 ± 12 |
| Heart weight (g) | 1.01 ± 0.05 | 2.31 ± 0.19a |
| LV weight (g) | 0.66 ± 0.03 | 1.23 ± 0.04a |
| LV/BW ratio (mg/g) | 1.8 ± 0.1 | 3.5 ± 0.2a |
| RV weight (g) | 0.17 ± 0.01 | 0.29 ± 0.02a |
| Lung weight (g) | 1.33 ± 0.05 | 3.28 ± 0.34a |
| Echocardiography | ||
| M-mode | ||
| IVSd (mm) | 1.6 ± 0.0 | 2.2 ± 0.1a |
| PWd (mm) | 1.6 ± 0.1 | 2.0 ± 0.1a |
| LVDd (mm) | 6.3 ± 0.2 | 7.3 ± 0.3a |
| LVDs (mm) | 3.4 ± 0.2 | 4.3 ± 0.5 |
| FS (%) | 55 ± 5 | 42 ± 5a |
| LAD (mm) | 3.5 ± 0.1 | 5.5 ± 0.4a |
| Doppler | ||
| Peak mitral flow (mm/s) | 908 ± 42 | 1039 ± 20 |
| Mitral deceleration (mm/s2) | 2974 ± 190 | 4243 ± 750 |
| HR (beats/min) | 438 ± 5 | 390 ± 19a |
| CO in LVOT (ml/min) | 130 ± 11 | 105 ± 12 |
| Tissue Doppler | ||
| Maximal systolic velocity (mm/s) | 70 ± 4 | 49 ± 8a |
| Minimal diastolic velocity (mm/s) | 72 ± 3 | 54 ± 5a |
a p < 0.05 SHAM versus ABHF.