TABLE 1.
Effects of mutations within and around the PyR1 and PyR2 receptors of insect sodium channels on the action of DDT
The following symbols are used: ↓, ↑, and ≈ indicate, respectively, decrease, increase, or insignificant change of the ligand potency.
| PyR1 |
PyR2 |
||||
|---|---|---|---|---|---|
| Mutant | Ref.a | Effect | Mutant | Ref.a | Effect |
| L2k7(914)F/I | 11 | = | |||
| M2k11(918)T | 11 | ↑ | V1k11A | This study | ↓ |
| L2o6(925)I | 11 | ↓ | L1o6I | This study | ↑ |
| T2o10(929)I | 11 | ↓ | I1o10C | This study | ≈ |
| L2o13(932)F | 11 | ↓ | T1o13A | This study | ≈ |
| C2o14(933)A | 11 | ↓ | |||
| I2o17(936)V | 11 | ↓ | |||
| F2i22S | This study | ↓ | I1i22A | This study | ↑ |
| L2i25A | This study | ↓ | I1i25A | This study | ≈ |
| I3i12A | This study | ↓ | V2i12A | This study | ≈ |
| F3i13C | This study | ↓ | I2i13M | This study | ↓ |
| F3i16A/S | This study | ↓ | L2i16F | This study, 9 | ↓ |