Alignment of gB protein homologs encoded by human herpesviruses. Overall sequence homology of gB conceptual translation from human herpesviruses (see Footnote 3) is shown schematically in grayscale (light gray, no homology; black, identity). Cys residues are highlighted with black squares above each sequence (asterisks mark conserved Cys); arrow points to HCMV gB Cys-777. The close-up view shows the alignment in the juxtamembrane-TM region. VZV, varicella zoster virus; HHV 6A, human herpesvirus 6A; HHV 7, human herpesvirus 7; KSHV, Kaposi's sarcoma-associated herpesvirus.