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. Author manuscript; available in PMC: 2016 Mar 30.
Published in final edited form as: J Neurogenet. 2016 Jan 4;29(4):174–177. doi: 10.3109/01677063.2015.1088847

Figure 3.

Figure 3

Protein Feature View for PRICKLE1 from the RCSB Protein Data Bank (PDB) website and a multiple species protein alignment of the region surrounding the amino acid change caused by the de novo mutation in PRICKLE1. An arrow indicates the reference amino acid (S) in humans and other vertebrates. The mutation is in the LIM zinc-binding 1-domain of PRICKLE1. The amino acid is completely conserved in the vertebrates used in the alignment, and is within a highly conserved domain across all species. Peptide sequences with high sequence similarity were downloaded from NCBI BLAST and the alignment was performed using the software ClustalW.