FIGURE 1.

Overview of the metabolic pathways in L. pneumophila Paris relevant for PHB formation and degradation. Key reactions investigated in this study are highlighted by underlined gene numbers. ¹³C-Labeled substrates used in this study are indicated by gray boxes. Analyzed metabolites are indicated by blue boxes. Gene numbers (lpp) are indicated in parentheses, genes given in green are more highly expressed in the exponential phase, whereas genes given in red are induced in the transmissive (PE) phase (13). Reactions affected in the mutant strains are indicated. FA, fatty acids. * refers to Ref. 48. The genes indicated here are generally present in all known genomes of Legionella strains. GAP, glyceraldehyde 3-phosphate; mTCA, methylcitrate cycle.