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The GLIC YPF motif. A, the ECD/TM interface in GLIC, highlighting the YPF motif in the cis conformation (PDB: 3EAM). B, relationship between mean pH50 values and cis-trans preferences for Pro analogs at Pro-119 in GLIC (filled circles), when compared with the analogous position (Pro-136) in the muscle-type nAChR (open squares) (17). Typical maximal currents for functional mutants generated by nonsense suppression were 0.5–2 μA, with P119Pip giving responses as high as 10 μA.
