FIGURE 5.

Clustered A-to-I editing occurs within regions of predicted secondary structure of cellular transcripts. RNA secondary structure predicted for unedited RNA within 200 nucleotides flanking the PCR amplicon for RPA1 (A) and DNAJC1 (B) transcripts that possess multiple A-to-I-editing sites. The region denoted by the bars corresponds to the enlarged image region and shows edited adenosines that largely cluster on one strand of the predicted duplex region of RPA1 but on both strands of DNAJC1.