FIGURE 8.

Structures of the bacterial fatty acid-binding protein family (FakB) and the substrate-binding protein/domain of the dihydroxyacetone kinase family (DhaK). The DhaK domain of C. freundii dihydroxyacetone kinase (PDB code 1UN9, residues 50–311) is superimposed on the FaKB2 crystal structure (PDB code 4X9X). The structural elements common to both proteins are the amino-terminal EDD (blue) and carboxyl-terminal domains (gold). The two structural elements the define the FakB family are an extension of the amino-terminal EDD domain by three sheets and one helix (dark purple) and a three-helix extension from the carboxyl-terminal domain (pink). The fatty acid of FakB2 is represented as charcoal-colored carbons and red-colored oxygen spheres. Pink dashes show the position of helix-8 in the FakB2 structure.