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. 2016 Mar 30;5:16027. doi: 10.1038/mtm.2016.27

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Tyrosine hydroxylase (TH) immunoreactivity after doxycycline induction. TH immunostaining was performed 9 weeks following intra-striatal injection of 8.0 × 10⁹ vg of AAV2/1-V16-hGDNF. (a–d) Representative pictures of TH immunoreactivity of rats fed with unsupplemented food (a) or Dox-supplemented diet containing 0.025 (b), 0.075 (c), 0.2 (d), or 1 gr of Dox/kg during 9 weeks. Scale bar: 2 mm (e) Values represent percentage of decrease of TH immunoreactivity relative to the striatum contralateral to the viral injection. n = 6 rats/Dox dose. ***P < 0.001 versus no Dox group and ^##P < 0.01 versus enhanced green fluorescent protein group). GDNF, glial cell line-derived neurotrophic factor.