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. 2016 Mar 7;213(3):451–463. doi: 10.1084/jem.20150688

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© 2016 Misra et al.

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Figure 5. — Enhanced integrin signaling in elastin mutants. (A) Aortic sections of WBS patient (age 46 yr) and age-matched human control stained for SMA, activated β3, and nuclei (DAPI); n = 3 patients. Asterisks signify activated integrin β3. (B–D) Transverse aortic sections of wild-type and Eln^(−/−) littermates at E18.5 or P1.5, stained for CD31, SMA, and nuclei (DAPI), and for either activated β3 (B), pFAK (C), or fibronectin (D). For each genotype, n = 3 mice. Lu, aortic lumen. Bars, 10 µm.