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. 2016 Jan 10;15(3):892–905. doi: 10.1074/mcp.M115.053280

Fig. 2.

Fig. 2.

Kme1 sites down-regulated following knockdown or inhibition of SMYD2. A, Volcano plot illustrating the normalized peptide ratio (shSMYD2/shControl) and p value distribution of Kme1 sites identified in control or SMYD2 knockdown cells. B, Volcano plot illustrating the (LLY-507/DMSO) and p value distribution of Kme1 sites identified in SMYD2-overexpressing KYSE-150 cells following treatment with LLY-507 or DMSO. C, Normalized peptide ratios of the SMYD2-dependent Kme1 site in HSP90AA1 (K615) upon SMYD2 knockdown as well as Kme1 sites known to be regulated by other PKMTs. D, Venn diagram illustrating the overlap in Kme1 sites (identified in at least two of three replicate experiments) identified in parental KYSE-150 and SMYD2-overexpressing cell lines. E, Venn diagram illustrating the number of Kme1 sites down-regulated by SMYD2 knockdown in parental KYSE-150 cells and by LLY-507 treatment in SMYD2-overexpressing cells. F, Normalized peptide ratios for Kme1 sites down-regulated in response to SMYD2 knockdown and to LLY-507 treatment.