Table III.
The thrombin inhibitory activity of the rhATs produced by CHO cells
Samplesa | Second-order rate constant |
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---|---|---|---|---|
Without heparin |
With heparin |
|||
(/M/s) | SD | (/M/s) | SD | |
rhAT-Manα | 6.6 × 103 | 1.1 × 102 | 1.9 × 107 | 2.2 × 105 |
rhAT-Manβ | 6.1 × 103 | 6.7 × 10 | 1.9 × 107 | 5.9 × 105 |
rhAT-Comα | 6.2 × 103 | 1.6 × 102 | 1.9 × 107 | 1.2 × 105 |
rhAT-Comβ | 7.3 × 103 | 3.3 × 102 | 2.0 × 107 | 1.2 × 105 |
SD, standard deviation.
aThe purified rhAT-Manα, rhAT-Manβ, rhAT-Comα and rhAT-Comβ were employed as samples.