Table 2.
Product | Low-molecular-weight iron dextran (Cosmofer) | Iron sucrose (Venofer) | Iron gluconate (Ferelecit) | Iron isomaltoside 1000 (Monofer) | Iron carboxymaltose (Ferinject) | Ferumoxytol (Feraheme) |
---|---|---|---|---|---|---|
Molecular weight, kDa | 165 | 34–60 | 290–440 | 150 | 150 | 750a |
pH | 5.2–6.5 | 10.5–11.1 | 7.7–9.7 | 5.0–7.0 | 5.0–7.0 | 6.0–8.0 |
Carbohydrate | Dextran branched polysaccharide | Sucrose disaccharide | Gluconate monosaccharide | Isomatoside unbranched linear oligosaccharide | Carboxymaltose branched polysaccharide | Oxide coated with polyglucose, sorbitol, carboxymethylether |
Maximum single dose | 20 mg/kg | 200 mg | 125 mg | 20 mg/kg | 15 mg/kg single dose limit 1000 mg | 510 mg |
Maximum single dose administration 80 kg male | 1600 mg | 200 mg | 125 mg | 1600 mg | 1000 mg | 510 mg |
Maximum single dose administration 60 kg female | 1200 mg | 200 mg | 125 mg | 1200 mg | 900 mg | 510 mg |
TDI repletion | Yes | No | No | YES | No | No |
Infusion within 1 h | No | NA | NA | Yes | Yes | Yes |
Iron concentration, mg/mL | 50 | 20 | 12.5 | 100 | 50 | 50 |
Test dose required | Yes | No/Yes (only Europe) | No | No | No | No |
Minimally analytical free iron | < 1% | 10% | 10–20% | < 0.1% | < 1% | < 0.1% |
Dose adjustment on dialysis | None | None | None | None | None | None |
aMolecular weight for ferumoxytol is not comparable to the other iron values because of measurement to a different standard