Table.
Summary of studies of metabolic syndrome among adult survivors of childhood ALL
| Author Year |
Time since diagnosis |
Age at evaluation |
Metabolic syndrome |
Increased waist circumference/ adiposity |
Elevated Triglycerides |
Low HDL-C | Hypertension | Elevated blood glucose |
Risk factors identified |
|---|---|---|---|---|---|---|---|---|---|
| (N) | years | Years | % | % | % | % | % | % | |
| Talvensaari [48] 1996 (28/50 with ALL) | Range 8–21 | 10–31 | 16.0% | 32% obese | No mean difference survivors vs. controls | Survivors lower mean values vs. controls | No mean difference survivors vs. controls | Higher mean values survivors vs. controls | GHD |
| Kourti [66] 2005 (52) | Median (since completion of therapy) 37 mo 3.1 years | Median 15.2 | 5.8% | 5.8% obese | 23.1% | 32.7% | – | – | – |
| Gurney [46] 2006 (75) | Mean 25.0 | Mean 30.0 | 16.6% | 41.7% | 20.6% | 63.5% | 21.1% | 9.9% | GHD and CRT |
| Trimis [67] 2007 (80) | Median (since completion of therapy) 6.3 years | Median 13.9 | 11.3% | 25.0% obese | 21.3% | 12.5% | 21.3% | 15.0% (high HbA1c) | CRT |
| van Waas* [49] 2010 (164/500 with ALL) | Median 19.0 | Median 28.0 | 13.0% | 9.2% | NR | 9.80% | 19.50% | 1.0% | CRT |
| Oudin [47] 2011 (184) | Median 15.4 | Median 21.2 | 9.2% | 14.5% | 13.0% | 31.8% | 25.3% | 5.7% | HCT with TBI |
| Nottage [42] 2014 (784) | Median 26.1 | Median 31.7 | 33.6% | 39.9% | 28.2% | 44.6% | 46.4% | 31.4% | CRT |
| Gunn [68] 2016 (N=226) | Mean 12.6 | Mean 18.0 | – | 32% obese | 50.0% with dyslipidemia among CRT exposed | = | 19.0% | 30.8% among CRT exposed | CRT |
HDL-C=High density lipoprotein cholesterol, GHD=Growth hormone deficiency, HCT=Hematopoietic cell transplantation, HbA1c=hemoglobin A1c, CRT=Cranial radiation Therapy, NR=Not reported,
*
Used a modified definition of metabolic syndrome with four components.