Figure 5.

QSN-10c inhibits capillary structure formation of endothelial cells on Matrigel. (A) HUVECs cultured on Matrigel were treated with only DMSO (0.1%). (B, C) HUVECs cultured on Matrigel were treated with 100 μmol/L of thalidomide and 4,6-dihydroxyisoindol-1,3-dione, respectively. (D–F) HUVECs cultured on Matrigel were treated with various concentrations of QSN-10c (50, 100, and 200 μmol/L). (G) Quantitative comparison of the numbers of branching points in different groups. Cells receiving only DMSO (0.1%) served as a vehicle control, thalidomide as a positive control. Data are expressed as percentages of the vehicle control (100%) in mean±SD from three independent experiments. ^bP<0.05, ^cP<0.01 compared with control.