Table 1. Lactoferrin immune response against pathogens.

Mechanism of action of Lf	Target	Reference
Enhancing of phagocytosis	Gram-Positive bacteria   S mutans   S epidermidis   S aureus Gram-Negative bacteria:   P aeruginosa   B cepacia   B cenocepacia   Porphyromonas gingivalis Virus:   VSV (Vesicular Stomatitis Virus) Fungi:   Candida spp.   A Fumigatus Parasites:   E histolytica   B caballi   T cruzi	6,84,121,122,54,84
Biofilms inhibition	Gram-Negative bacteria:   Porphyromonas gingivalis   Prevetella intermedi   P aeruginosa   B cepacia   B cenocepacia   E coli   M bovis Gram-Positive bacteria:   S epidermidis	84,87,92,123
Positive domain union with negative charges on microorganisms	Gram-Negative bacteria:   E coli Parasites:   T gondii   E stiedai	6,124
Modification of the interactions of microbes, with the host cells, or with the extracellular matrix	Gram-Positive bacteria:   B subtilis   K pneumoniae   S mutans Virus:   Rotavirus   Enterovirus	84,87
Inhibits LPS-mediated activation	Gram-Negative bacteria	6,85,125
Induction of apoptosis	Fungi:   Candida albicans	90