Table 3. Genotype and allele distribution for IL18 polymorphisms in asymptomatic and chronic Chagas cardiomyopathy (CCC) individuals.
| Genotype. N (%) | Allele test | |||||||
|---|---|---|---|---|---|---|---|---|
| SNP | 1|2 | Group (N) | 1|1 | 1|2 | 2|2 | MAF % | P | OR [95% CI] |
| rs5744258 | C|G | Asymptomatic (175) | 0 (0.00) | 37 (21.14) | 138 (78.86) | 10.57 | ||
| CCC (395) | 2 (0.51) | 91 (23.04) | 302 (76.46) | 12.03 | 0.4792 | 1.16 [0.77–1.73] | ||
| rs360722 | T|C | Asymptomatic (174) | 4 (2.30) | 29 (16.67) | 141 (81.03) | 10.63 | ||
| CCC (398) | 7 (1.75) | 90 (22.56) | 301 (75.69) | 13.07 | 0.2409 | 1.26 [0.85–1.88] | ||
| rs2043055 | C|T | Asymptomatic (173) | 36 (20.81) | 78 (45.09) | 59 (34.10) | 43.35 | ||
| CCC (395) | 62 (15.70) | 203 (51.39) | 130 (32.91) | 41.39 | 0.5378 | 0.92 [0.71–1.19] | ||
| rs187238 | C|G | Asymptomatic (173) | 25 (14.45) | 74 (42.77) | 74 (42.77) | 35.84 | ||
| CCC (399) | 42 (10.53) | 185 (46.37) | 172 (43.11) | 33.71 | 0.4862 | 0.91 [0.70–1.19] | ||
| rs1946518 | A|C | Asymptomatic (175) | 45 (25.71) | 80 (45.71) | 50 (28.57) | 48.57 | ||
| CCC (397) | 87 (21.91) | 203 (51.13) | 107 (26.95) | 47.48 | 0.7337 | 0.96 [0.74–1.23] | ||
| rs360719 | C|T | Asymptomatic (174) | 26 (14.94) | 75 (43.10) | 73 (41.95) | 36.49 | ||
| CCC (398) | 41 (10.30) | 183 (45.98) | 174 (43.72) | 33.29 | 0.2937 | 0.87 [0.67–1.13] | ||