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. 2016 Mar 30;12(3):e1005960. doi: 10.1371/journal.pgen.1005960

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© 2016 Gupta, Adami

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — Changes in per-site entropies (top panel), residue isoelectric point (middle panel), and residue weights (bottom panel) due to treatment. The property difference at each site is obtained by subtracting property (entropy/pI/residue-weight) value of the untreated data from that of the treated data. Average values are obtained by sampling sequence data from all years (1998–2006, 10 subsamples/year of 300 sequences each). Error bars represent ±1 SE. Red dots represent positions known to be primary drug resistance loci, while black dots mark positions of compensatory or accessory mutations [52]. Resistance loci are shaded in red and accessory loci are shaded in black.